In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae
Multidrug-resistant (MDR) Klebsiella pneumoniae is a top-prioritized Gram-negative pathogen with a high incidence in hospital-acquired infections. Polymyxins have resurged as a last-line therapy to combat Gram-negative “superbugs”, including MDR K. pneumoniae. However, the emergence of polymyxin res...
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Main Authors: | Yean Chung, Wan, Abdul Rahim, Nusaibah, Mahamad Maifiah, Mohd Hafidz, Hawala Shivashekaregowda, Naveen Kumar, Zhu, Yan, Wong, Eng Hwa |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022
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Subjects: | |
Online Access: | http://irep.iium.edu.my/99214/7/99214_In%20silico%20genome-scale%20metabolic%20modeling.pdf http://irep.iium.edu.my/99214/ https://www.frontiersin.org/articles/10.3389/fphar.2022.880352/pdf https://doi.org/10.3389/fphar.2022.880352 |
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