Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor

• Main Authors: Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, M.Yamin, Bohari, Baharuddin, Mohd Syukri, Ismail, Nor Hadiani, YudaTeruna, Hilwan, Abbas Bukhari, Syed Nasir, Jantan, Ibrahim, Jalil, Juriyati, Husain, Khairana, Lam, Kok Wai
• Format: Article
• Language: English
• Published: Elsevier 2015
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/73535/1/Kamal%20Rullah%204.pdf; http://irep.iium.edu.my/73535/; https://www.sciencedirect.com/science/article/abs/pii/S0022286014010059

The present study aimed to characterize and investigate 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one (22) as a novel selective COX-2 inhibitor. The data collected from the single X-ray crystallographic analysis and in silico study provide important insights on the molecular...