In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae

• Main Authors: Yean Chung, Wan, Abdul Rahim, Nusaibah, Mahamad Maifiah, Mohd Hafidz, Hawala Shivashekaregowda, Naveen Kumar, Zhu, Yan, Wong, Eng Hwa
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2022
• Subjects: QR Microbiology; RM300 Drugs and their action; RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/99214/7/99214_In%20silico%20genome-scale%20metabolic%20modeling.pdf; http://irep.iium.edu.my/99214/; https://www.frontiersin.org/articles/10.3389/fphar.2022.880352/pdf; https://doi.org/10.3389/fphar.2022.880352

Multidrug-resistant (MDR) Klebsiella pneumoniae is a top-prioritized Gram-negative pathogen with a high incidence in hospital-acquired infections. Polymyxins have resurged as a last-line therapy to combat Gram-negative “superbugs”, including MDR K. pneumoniae. However, the emergence of polymyxin res...