Metabolic responses to polymyxin treatment in acinetobacter baumannii ATCC 19606: integrating transcriptomics and metabolomics with genome-scale metabolic modeling

• Main Authors: Zhu, Yan, Zhao, Jinxin, Mahamad Maifiah, Mohd Hafidz, Velkov, Tony, Schreiber, Falk, Lia, Jian
• Format: Article
• Language: English; English
• Published: American Society for Microbiology 2019
• Subjects: QR Microbiology; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/70940/7/70940_Metabolic%20Responses%20to%20Polymyxin_wos.pdf; http://irep.iium.edu.my/70940/13/70940_%20Metabolic%20responses%20to%20polymyxin%20treatment%20in%20acinetobacter%20baumannii%20ATCC%2019606.pdf; http://irep.iium.edu.my/70940/; https://msystems.asm.org/content/msys/4/1/e00157-18.full.pdf

Multidrug-resistant (MDR) Acinetobacter baumannii has emerged as a very problematic pathogen over the past decades, with a high incidence in nosocomial infections. Discovered in the late 1940s but abandoned in the 1970s, polymyxins (i.e., polymyxin B and colistin) have been revived as the last-line...