Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa

• Main Authors: Zhu, Yan, Czauderna, Tobias, Zhao, Jinxin, Klapperstueck, Matthias, Maifiah, Mohd Hafidz Mahamad, Han, Mei-Ling, Lu, Jing, Sommer, Björn, Velkov, Tony, Lithgow, Trevor, Song, Jiangning, Schreiber, Falk, Li, Jian
• Format: Article
• Language: English
• Published: Oxford Academic 2018
• Subjects: QR Microbiology; RM Therapeutics. Pharmacology; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/65380/1/2018_giy021.pdf; http://irep.iium.edu.my/65380/; https://academic.oup.com/gigascience/article/7/4/giy021/4931736?searchresult=1

Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients, and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibioti...