Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae

Carbapenemase-resistant Klebsiella pneumoniae (KP) resistant to multiple antibiotic classes necessitates optimized combination therapy. Our objective is to build a workflow leveraging omics and bacterial count data to identify antibiotic mechanisms that can be used to design and optimize combination...

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Bibliographic Details
Main Authors: Hanafin, Patrick O., Abdul Rahim, Nusaibah, Sharma, Rajnikant, Cess, Colin G., Finley, Stacey D., Bergen, Phillip J., Velkov, Tony, Li, Jian, Rao, Gauri G.
Format: Article
Published: Wiley 2023
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Online Access:http://eprints.um.edu.my/38694/
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