In silico functional and structural insight of prenylated pyrazolocurcumin derivative associated with the PGE2 inhibition through mPGES-1 blocking

• Main Authors: Mohd Aluwi, Mohd Fadhlizil Fasihi, Salim, Fatimah, Moyeenul Huq, A.K.M., Rullah, Kamal, Kok Wai, Lam
• Other Authors: Edy Sutjipto, Agus Geter
• Format: Conference or Workshop Item
• Language: English; English; English
• Published: Trans Tech Publications Ltd 2021
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/89989/1/MSF.1025.219.pdf; http://irep.iium.edu.my/89989/2/MSF.1025.219; http://irep.iium.edu.my/89989/8/89989_Scopus%20-%20In%20silico%20functional%20and%20structural%20insight%20of%20prenylated%20pyrazolocurcumin%20derivative.pdf; http://irep.iium.edu.my/89989/; https://www.scientific.net/MSF.1025.219; https://doi.org/10.4028/www.scientific.net/MSF.1025.219

The search of novel mPGES-1 lead inhibitors has recently become subject of interest to medicinal chemists due to the safety in comparison to existing NSAIDs such as coxibs drugs. The recent published work revealed that prenylated pyrazolocurcumin derivative as mPGES-1 has been sucessfully designed a...