Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor
The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of...
Saved in:
Main Authors: | Chean, Hui Ng, Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, Abas, Faridah, Kok, Wai Lam, Ismail, Intan Safinar, Narayanaswamy, Radhakrishnan, Jamaludin, Fadzureena, Shaari, Khozirah |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI
2014
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/73318/1/Kamal%20Rullah%203.pdf http://irep.iium.edu.my/73318/ https://www.mdpi.com/1420-3049/19/8/11645 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment
by: Ng, Chean Hui, et al.
Published: (2018) -
Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses
by: Rullah, Kamal, et al.
Published: (2022) -
Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme
by: Rullah, Kamal, et al.
Published: (2018) -
Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-1
by: Sanphetchaloemchok, Pitipat, et al.
Published: (2020) -
Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
by: Rullah, Kamal, et al.
Published: (2019)