Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents

• Main Authors: Leong, Sze Wei, Mohd Faudzi, Siti Munirah, Abas, Faridah, Mohd Aluwi, Mohd Fadhlizil Fasihi, Rullah, Kamal, Lam, Kok Wai, Abdul Bahari, Mohd Nazri, Ahmad, Syahida, Chau, Ling Tham, Shaari, Khozirah, Lajis, Nordin H.
• Format: Article
• Language: English
• Published: MDPI 2014
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/73537/1/Kamal%20Rullah%205.pdf; http://irep.iium.edu.my/73537/; https://www.mdpi.com/1420-3049/19/10/16058

A series of ninety-seven diarylpentanoid derivatives were synthesized and evaluated for their anti-inflammatory activity through NO suppression assay using interferone gamma (IFN-γ)/lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Twelve compounds (9, 25, 28, 43, 63, 64, 81, 83, 84, 86, 88...