Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives

• Main Authors: Leong, Sze Wei, Mohd Faudzi, Siti Munirah Mohd Faudzi, Abas, Faridah, Mohd Aluwi, Mohd Fadhlizil Fasihi, Rullah, Kamal, Lam, Kok Wai, Abdul Bahari, Mohd Nazri, Ahmad, Syahida, Tham, Chau Ling, Shaari, Khozirah, Lajis, Nordin H.
• Format: Article
• Language: English
• Published: Elsevier 2015
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/73756/1/Kamal%20Rullah%209.pdf; http://irep.iium.edu.my/73756/; https://www.sciencedirect.com/science/article/pii/S0960894X15005302

A series of twenty-four 2-benzoyl-6-benzylidenecyclohexanone analogs were synthesized and evaluated for their nitric oxide inhibition and antioxidant activity. Six compounds (3, 8, 10, 17, 18 and 19) were found to exhibit significant NO inhibitory activity in LPS/IFN-induced RAW 264.7 macrophages,...