Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor

• المؤلفون الرئيسيون: Chean, Hui Ng, Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, Abas, Faridah, Kok, Wai Lam, Ismail, Intan Safinar, Narayanaswamy, Radhakrishnan, Jamaludin, Fadzureena, Shaari, Khozirah
• التنسيق: مقال
• اللغة: English
• منشور في: MDPI 2014
• الموضوعات: RS403 Materia Medica-Pharmaceutical Chemistry
• الوصول للمادة أونلاين: http://irep.iium.edu.my/73318/1/Kamal%20Rullah%203.pdf; http://irep.iium.edu.my/73318/; https://www.mdpi.com/1420-3049/19/8/11645

The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of...