Anti-allergic activity of 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) via attenuation of IgE-mediated mast cell activation and inhibition of passive systemic anaphylaxis

• Main Authors: Tan, Ji Wei, Israf Ali, Daud Ahmad, Harith, Hanis Hazeera, Md Hashim, Nur Fariesha, Ng, Chean Hui, Shaari, Khozirah, Tham, Chau Ling
• Format: Article
• Language: English
• Published: Elsevier 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/55602/1/Anti-allergic%20activity%20of%202%2C4%2C6-trihydroxy-3-geranylacetophenone%20%28tHGA%29%20via%20attenuation%20of%20IgE-mediated%20mast%20cell%20activation%20and%20inhibition%20of%20passive%20systemic%20anaphylaxis.pdf; http://psasir.upm.edu.my/id/eprint/55602/; http://www.sciencedirect.com/science/article/pii/S0041008X17300595

tHGA, a geranyl acetophenone compound originally isolated from a local shrub called Melicope ptelefolia, has been previously reported to prevent ovalbumin-induced allergic airway inflammation in a murine model of allergic asthma by targeting cysteinyl leukotriene synthesis. Mast cells are immune eff...