Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor

• Main Authors: Chean, Hui Ng, Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, Abas, Faridah, Kok, Wai Lam, Ismail, Intan Safinar, Narayanaswamy, Radhakrishnan, Jamaludin, Fadzureena, Shaari, Khozirah
• Format: Article
• Language: English
• Published: MDPI 2014
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/73318/1/Kamal%20Rullah%203.pdf; http://irep.iium.edu.my/73318/; https://www.mdpi.com/1420-3049/19/8/11645

The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of...