Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors

• Main Authors: Mohd Faudzi, Siti Munirah Mohd Faudzi, Leong, Sze Wei, Abas, Faridah, Mohd Aluwi, Mohd Fadhlizil Fasihi, Rullah, Kamal, Lam, Kok Wai, Ahmad, Syahida, Ling Tham, Chau Ling Tham, Lajis, Nordin H.
• Format: Article
• Language: English
• Published: Royal Society of Chemistry (RSC) 2015
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/73544/1/Kamal%20Rullah%207.pdf; http://irep.iium.edu.my/73544/; https://pubs.rsc.org/en/content/articlelanding/2015/md/c4md00541d#!divAbstract

A series of forty-five 1,5-diphenylpenta-2,4-dien-1-one analogues were synthesized and evaluated for their nitric oxide (NO) inhibition activity in IFN-γ/LPS-activated RAW 264.7 cells. Compounds 3h, 7a, 7d and 7e exhibited comparable or significantly higher activity than the standard, curcumin (IC50...