Synthesis, biological evaluation and molecular modelling of 2′-hydroxychalcones as acetylcholinesterase inhibitors

• Main Authors: Sukumaran, S.D., Chee, C.F., Viswanathan, G., Buckle, M.J.C., Othman, R., Rahman, N.A., Chung, L.Y.
• Format: Article
• Language: English
• Published: 2017

A series of 2′-hydroxy- and 2′-hydroxy-4′,6′-dimethoxychalcones was synthesised and evaluated as inhibitors of human acetylcholinesterase (AChE). The majority of the compounds were found to show some activity, with the most active compounds having IC50 values of 40-85 μM. Higher activities were gene...