Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids.

• Main Authors: Hasan, Aso Hameed, Shakya, Sonam, Hussain, Faiq H.S., Murugesan, Sankaranarayanan, Chander, Subhash, Pratama, Mohammad Rizki Fadhil, Jamil, Shajarahtunnur, Das, Basundhara, Biswas, Subhrajit, Jamalis, Joazaizulfazli
• Format: Article
• Published: Taylor and Francis Ltd. 2023
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/106288/; http://dx.doi.org/10.1080/07391102.2022.2162583

The major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors (AChEIs) are the most prescribed class of medications for the treatment of Alzheimer’s disease (AD) and dementia. The limitations of a...