2-Aryl-3-(arylideneamino)-1,2-dihydroquinazoline-4(3H)-ones as inhibitors of cholinesterases and self-induced β-amyloid (Aβ) aggregation: biological evaluations and mechanistic insights from molecular dynamics simulations

• Main Authors: Sukumaran, Sri Devi, Faraj, Fadhil Lafta, Lee, Vannajan Sanghiran, Othman, Rozana, Buckle, Michael James Christopher
• Format: Article
• Published: Royal Society of Chemistry 2018
• Subjects: Q Science (General); QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/20600/; https://doi.org/10.1039/c7ra11872d

A series of 2-aryl-3-(arylideneamino)-1,2-dihydroquinazoline-4(3H)-ones were evaluated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and self-induced β-amyloid (Aβ) aggregation. All the compounds were found to inhibit both forms of cholinesterase (IC50 in the range 4-32...