Analogues of 2 `-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase

• Main Authors: Sukumaran, Sri Devi, Nasir, Shah Bakhtiar, Tee, Jia Ti, Buckle, Michael J. C., Othman, Rozana, Abd Rahman, Noorsaadah, Lee, Vannajan Sanghiran, Bukhari, Syed Nasir Abbas, Chee, Chin Fei
• Format: Article
• Published: Taylor & Francis Ltd 2021
• Subjects: QD Chemistry; QH301 Biology; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/34280/

A series of C4-substituted tertiary nitrogen-bearing 2 `-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2 `-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylcholinest...