An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines

• Main Authors: Almansour, Abdulrahman I., Kumar, Raju Suresh, Arumugam, Natarajan, Basiri, Alireza, Kia, Yalda, Ali, Mohamed Ashraf
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2015
• Subjects: QD1-999 Chemistry; RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/38309/1/An_Expedient_Synthesis%2C_Acetylcholinesterase_Inhibitory_Activity%2C_and_Molecular.pdf; http://eprints.usm.my/38309/; http://dx.doi.org/10.1155/2015/965987

A series of hexahydro-1,6-naphthyridines were synthesized in good yields by the reaction of 3,5-bis[(E)-arylmethylidene] tetrahydro-4(1H)-pyridinones with cyanoacetamide in the presence of sodium ethoxide under simple mixing at ambient temperature for 6–10 minutes and were assayed for their acetyl...