Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group

• Main Authors: Yeoh, A.E.J., Lu, Y., Chan, J.Y.S., Chan, Y.H., Ariffin, H., Kham, S.K.Y., Quah, T.C.
• Format: Article
• Published: Elsevier 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/15166/

To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers ma...