Associations of T-cell receptor repertoire diversity with L-asparaginase allergy in childhood acute lymphoblastic leukemia

• Main Authors: Lee, Shawn H. R., Li, Zhenhua, Lim, Evelyn H. Z., Chin, Winnie H. N., Jiang, Nan, Chiew, Kean Hui, Chen, Zhiwei, Oh, Bernice L. Z., Tan, Ah Moy, Ariffin, Hany, Yang, Jun J., Yeoh, Allen E. J.
• Format: Article
• Published: MDPI 2023
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/38518/

Simple Summary Asparaginase allergy is the most common side effect of childhood acute lymphoblastic leukemia (ALL) therapy and may affect survival outcomes, but the basis of T-cell responses-especially the T-cell receptor (TCR) repertoire-is unknown. The aim of this study was to characterize the ass...