Expression of p53 N-terminal isoforms in B-cell precursor acute lymphoblastic leukemia and its correlation with clinicopathological profiles

• Main Authors: Oh, Lixian, Hainaut, Pierre, Blanchet, Sandrine, Ariffin, Hany
• 格式: Article
• 出版: BioMed Central 2020
• 主题: R Medicine
• 在线阅读: http://eprints.um.edu.my/25503/; https://doi.org/10.1186/s12885-020-6599-8

Background: TP53 mutations occur in only about 3% of primary and 10-20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative mechanisms may contribute to functionally impairing the p53 pathway in the absence of a mutation. Candidate mechanisms include overexpress...