Intracellular vincristine levels in lymphoblasts affect treatment outcome in childhood B-lymphoblastic leukaemia: Ma-Spore ALL 2010 study

• Main Authors: Jiang, Nan, Wang, Lingzhi, Xiang, Xiaoqiang, Li, Zhenhua, Chiew, Edwynn Kean Hui, Koo, Yok Moi, Lee, How Sung, Lin, Hai Peng, Tan, Ah Moy, Quah, Thuan Chong, Kham, Shirley Kow Yin, Goh, Boon Cher, Ariffin, Hany, Yeoh, Allen Eng-Juh
• Format: Article
• Published: Wiley 2021
• Subjects: R Medicine; R Medicine (General)
• Online Access: http://eprints.um.edu.my/34526/

Aims Vincristine (VCR) is a key drug in the successful multidrug chemotherapy for childhood acute lymphoblastic leukaemia (ALL). However, it remains unclear how VCR pharmacokinetics affects its antileukaemic efficacy. The objective of this study is to explore the VCR pharmacokinetic parameters and i...