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Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group

To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers ma...

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Main Authors: Yeoh, A.E.J., Lu, Y., Chan, J.Y.S., Chan, Y.H., Ariffin, H., Kham, S.K.Y., Quah, T.C.
Format: Article
Published: Elsevier 2010
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/15166/
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spelling my.um.eprints.151662015-12-22T02:03:23Z http://eprints.um.edu.my/15166/ Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group Yeoh, A.E.J. Lu, Y. Chan, J.Y.S. Chan, Y.H. Ariffin, H. Kham, S.K.Y. Quah, T.C. R Medicine To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6 bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. (C) 2009 Elsevier Ltd. All rights reserved. Elsevier 2010 Article PeerReviewed Yeoh, A.E.J. and Lu, Y. and Chan, J.Y.S. and Chan, Y.H. and Ariffin, H. and Kham, S.K.Y. and Quah, T.C. (2010) Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group. Leukemia Research, 34 (3). pp. 276-283.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Yeoh, A.E.J.
Lu, Y.
Chan, J.Y.S.
Chan, Y.H.
Ariffin, H.
Kham, S.K.Y.
Quah, T.C.
Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group
description To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6 bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. (C) 2009 Elsevier Ltd. All rights reserved.
format Article
author Yeoh, A.E.J.
Lu, Y.
Chan, J.Y.S.
Chan, Y.H.
Ariffin, H.
Kham, S.K.Y.
Quah, T.C.
author_facet Yeoh, A.E.J.
Lu, Y.
Chan, J.Y.S.
Chan, Y.H.
Ariffin, H.
Kham, S.K.Y.
Quah, T.C.
author_sort Yeoh, A.E.J.
title Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group
title_short Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group
title_full Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group
title_fullStr Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group
title_full_unstemmed Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore all study group
title_sort genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in malay boys: results from the malaysia-singapore all study group
publisher Elsevier
publishDate 2010
url http://eprints.um.edu.my/15166/
_version_ 1643689996344885248
score 13.159267

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