Curcumin Analog DK1 Induces Apoptosis in Human Osteosarcoma Cells In Vitro through Mitochondria-Dependent Signaling Pathway

• Main Authors: Muhammad Nazirul Mubin, Aziz, Yazmin, Hussin, Nurul Fattin, Che Rahim, Noraini, Nordin, Nurul Elyani, Mohamad, Swee, Keong Yeap, Chean, Yeah Yong, Akhtar, Muhammad Nadeem, Mas Jaffri, Masarudin, Yoke, Kqueen Cheah, Nadiah, Abu, Noorjahan Banu, Alitheen
• Format: Article
• Language: English
• Published: MDPI - Open Access Publishing 2018
• Subjects: Q Science (General); T Technology (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/20313/1/Curcumin%20Analog%20DK1%20Induces%20Apoptosis%20in%20Human%20Osteosarcoma%20Cells%20In%20Vitro%20through%20Mitochondria%20Dependent%20Signaling%20Pathway.pdf; http://umpir.ump.edu.my/id/eprint/20313/; https://doi.org/10.3390/molecules23010075; https://doi.org/10.3390/molecules23010075

Osteosarcoma is one of the primary malignant bone tumors that confer low survival rates for patients even with intensive regime treatments. Therefore, discovery of novel anti-osteosarcoma drugs derived from natural products that are not harmful to the normal cells remains crucial. Curcumin is one of...