Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy

• Main Authors: Haerian, B.S., Lim, K.S., Mohamed, E.H.M., Tan, H.J., Tan, C.T., Raymond, A.A., Wong, C.P., Wong, S.W., Mohamed, Z.
• Format: Article
• Language: English
• Published: 2011
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/5080/1/Haerian-2011-Lack_of_association.pdf; http://eprints.um.edu.my/5080/

It is proposed that overexpression of P-glycoprotein (P-gp), encoded by the ABC subfamily B member 1 (ABCB1) gene, is involved in resistance to antiepileptic drugs (AEDs) in about 30 of patients with epilepsy. Genetic variation and haplotype patterns are population specific which may cause different...