Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients

• Main Authors: Haerian, B.S., Lim, K.S., Tan, H.J., Mohamed, E.H.M., Tan, C.T., Raymond, A.A., Wong, C.P., Wong, S.W., Omar, H., Roslan, H., Mohamed, Z.
• Format: Article
• Published: 2011
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/5071/

Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30 of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy p...