Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy

• Main Authors: Haerian, B.S., Lim, K.S., Mohamed, E.H.M., Tan, H.J., Tan, C.T., Raymond, A.A., Wong, C.P., Wong, S.W., Mohamed, Z.
• Format: Article
• Language: English
• Published: 2011
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/5088/1/Haerian-2011-Lack_of_association.pdf; http://eprints.um.edu.my/5088/

Approximately one third of newly treated epilepsy patients do not respond to antiepileptic drugs (AEDs). Overexpression of P-glycoprotein (P-gp) efflux transporter has been proposed to have a critical role in causing resistance to AEDs. P-gp is a product of the ATP-binding cassette subfamily B membe...