Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review

• Main Authors: Haerian, B.S., Mohamed, Z., Mohamed, E.H.M., Lim, K.S., Tan, H.J., Tan, C.T., Raymond, A.A.
• Format: Article
• Language: English
• Published: 2009
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/5095/1/Role_of_ABCB1_C3435T_Variant_in_Response.pdf; http://eprints.um.edu.my/5095/

Over-expression of P-glycoprotein (P-gp), the encoded product of the ATP-binding cassette (ABC), sub-family B, member 1 (ABCB1/MDR1) gene, plays an important role in mediating multidrug resistance to antiepileptic drugs (AEDs) in about 30 of patients with epilepsy. Genetic variation may in part expl...