Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells

• Main Authors: Kamato, Danielle, Rostam, Muhamad Ashraf, Piva, Terence J., Rezaei, Hossein B., Getachew, Robel, Thach, Lyna, Bernard, Rebekah, Zheng, Wenhua, Little, Peter J., Osman, Narin
• Format: Article
• Language: English
• Published: Wiley 2014
• Subjects: QP Physiology; RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/55283/1/5.%20Kamato-2014-Transforming%20growth%20factor%20%CE%B2-media.pdf; http://irep.iium.edu.my/55283/; http://onlinelibrary.wiley.com/doi/10.1111/jphp.12298/abstract

Objectives Transforming growth factor (TGF)-β regulates the function of vascular endothelial cells and may be involved in endothelial dysfunction. The canonical TGF-β pathway involves TGF-β receptor-mediated carboxy-terminal phosphorylation of Smad2; however, TGF-β signalling also activates numer...