Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2

• Main Authors: Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terence J., Cao, Yingnan, Zheng, Wenhua, Osman, Narin, Little, Peter J.
• Format: Article
• Language: English; English
• Published: American Society for Pharmacology and Experimental Therapeutics 2018
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/62174/7/62174_Flavopiridol%20Inhibits%20TGF-%CE%B2-Stimulated%20Biglycan_article.pdf; http://irep.iium.edu.my/62174/8/62174_Flavopiridol%20Inhibits%20TGF-%CE%B2-Stimulated%20Biglycan_scopus.pdf; http://irep.iium.edu.my/62174/; http://jpet.aspetjournals.org/content/early/2018/02/09/jpet.117.244483.long

Transforming Growth Factor (TGF) β is a pleiotropic growth factor implicated in the development of atherosclerosis for its role in mediating glycosaminoglycan (GAG) chain hyperelongation on the proteoglycan biglycan, a phenomenon that leads to increased binding of atherogenic lipoproteins in the wal...