Heparanase and vascular endothelial growth factor expression in the progression of oral mucosal melanoma

• Main Authors: Rivera, R.S., Nagatsuka, H., Siar, C.H., Gunduz, M., Tsujigiwa, H., Han, P.P., Katase, N., Tamamura, R., Ng, K.H., Naomoto, Y., Nakajima, M., Nagai, N.
• Format: Article
• Language: English
• Published: 2008
• Subjects: RK Dentistry
• Online Access: http://eprints.um.edu.my/4311/1/Heparanase_and_vascular_endothelial_growth_factor_expression_in_the_progression_of_oral_mucosal_melanoma.pdf; http://eprints.um.edu.my/4311/

Oral mucosal melanoma is an aggressive neoplasm with poor prognosis. Heparanase is an endo-beta-d-glucuronidase, which cleaves heparan sulphate chains. The vascular endothelial growth factor (VEGF) is the most potent angiogenic mitogen and interaction with its receptor (VEGFR) has been associated wi...