Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis

• Main Authors: Afroz, Rizwana, Cao, Yingnan, Rostam, Muhamad Ashraf, Ta, Hang, Xu, Suowen, Zheng, Wenhua, Osman, Narin, Kamato, Danielle, Little, Peter J.
• Format: Article
• Language: English; English; English
• Published: Elsevier 2018
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/62249/1/62249_Signalling%20pathways%20regulating%20galactosaminoglycan.pdf; http://irep.iium.edu.my/62249/2/62249_Signalling%20pathways%20regulating%20galactosaminoglycan_SCOPUS.pdf; http://irep.iium.edu.my/62249/3/62249_Signalling%20pathways%20regulating%20galactosaminoglycan_WOS.pdf; http://irep.iium.edu.my/62249/; https://doi.org/10.1016/j.pharmthera.2018.02.005

Atherosclerosis commences with the trapping of low density lipoproteins (LDLs) in blood vessels by modified proteoglycans (PGs) with hyperelongated glycosaminoglycan (GAG) chains. GAG chain synthesis and growth factor mediated hyperelongation regulates the composition and size of PGs in a manner tha...