Real-Time High Resolution Melting Analysis-PCR for Assessment of Gene Mutations in Human Autosomal Dominant Polycystic Kidney Disease

• Main Author: Mohd Jas, Rusni
• Format: Thesis
• Language: English
• Published: 2011
• Subjects: Polycystic Kidney, Autosomal Dominant
• Online Access: http://psasir.upm.edu.my/id/eprint/21581/1/FPSK%28m%29_2011_31R.pdf; http://psasir.upm.edu.my/id/eprint/21581/

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary renal diseases that affect 1 in 400 to 1 in 1000 life birth and cause by mutations in two known genes; PKD1 and PKD2. Although the manifestation of Type1 ADPKD is similar to Type2, it is more severe and patient...