Genotyping of GATA4 gene variant (G296S) in Malaysian congenital heart disease subjects by real-time PCR high resolution melting analysis

• Main Authors: Fawzi, Nora, Vasudevan, Ramachandran, Ismail, Patimah, Alwi, Mazeni, Abdul Aziz, Ahmad Fazli, Almeamar, Hussein, Mohamad, Nur Afiqa, Etemad, Ali
• Format: Article
• Published: De Gruyter Open 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29558/; http://www.degruyter.com/view/j/jomb.2013.32.issue-2/jomb-2013-0006/jomb-2013-0006.xml

Background: Congenital heart disease (CHD) is the most common birth defect; however, the underlying etiology is unrecognized in the majority of cases. GATA-binding protein 4 (GATA4), a cardiac transcription factor gene, has a crucial role in the cardiogenesis process; hence, a number of heterozygote...