Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment

• Main Authors: Ramli, Amirah Hani, Swain, Puspanjali, Mohd Fahmi, Muhammad Syafiq Akmal, Abas, Faridah, Leong, Sze Wei, Tejo, Bimo Ario, Shaari, Khozirah, Ali, Amatul Hamizah, Agustar, Hani Kartini, Awang, Rusdam, Ng, Yee Ling, Lau, Yee Ling, Md Razali, Mohammad Aidiel, Mastuki, Siti Nurulhuda, Mohmad Misnan, Norazlan, Mohd Faudzi, Siti Munirah, Kim, Cheol-Hee
• Format: Article
• Language: English
• Published: Elsevier 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/112060/1/PIIS2405844024034935.pdf; http://psasir.upm.edu.my/id/eprint/112060/; https://www.cell.com/heliyon/fulltext/S2405-8440(24)03493-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844024034935%3Fshowall%3Dtrue

Malaria remains a major public health problem worldwide, including in Southeast Asia. Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug resistance and toxicity have necessitated a continuous search for new effective antimalarial agents. Here we report on a virtua...