In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models

• Main Authors: Muhammad Syafiq, Akmal Mohd Fahmi, Swain, Puspanjali, Amirah, Hani Ramli, Wan Norhamidah, Wan Ibrahim, Nur Atikah, Saleh Hodin, Noraini, Abu Bakar, Tan, Yee Seng *, Siti Munirah, Mohd Faudzi, Kim, Cheol-Hee
• Format: Article
• Language: English
• Published: Elsevier 2023
• Subjects: QD Chemistry
• Online Access: http://eprints.sunway.edu.my/2176/1/1-s2.0-s2405844023008927-main.pdf; http://eprints.sunway.edu.my/2176/; https://doi.org/10.1016/j.heliyon.2023.e13685

Epilepsy is the third most common known brain disease worldwide. Several antiepileptic drugs (AEDs) are available to improve seizure control. However, the associated side effects limit their practical use and highlight the ongoing search for safer and effective AEDs. Eighteen newly designed fluorine...