In silico studies, X-ray diffraction analysis and biological investigation of fluorinated pyrrolylated-chalcones in zebrafish epilepsy models

• Main Authors: Mohd Fahmi, Muhammad Syafiq Akmal, Swain, Puspanjali, Ramli, Amirah Hani, Wan Ibrahim, Wan Norhamidah, Saleh Hodin, Nur Atikah, Abu Bakar, Noraini, Tan, Yee Seng, Mohd Faudzi, Siti Munirah, Kim, Cheol-Hee
• Format: Article
• Published: Elsevier 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/109225/; https://linkinghub.elsevier.com/retrieve/pii/S2405844023008927

Epilepsy is the third most common known brain disease worldwide. Several antiepileptic drugs (AEDs) are available to improve seizure control. However, the associated side effects limit their practical use and highlight the ongoing search for safer and effective AEDs. Eighteen newly designed fluor...