Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review

• Main Authors: Haerian BS,, Mohamed Z,, Mohamed EHM,, Lim KS,, Tan HJ,, Tan CT,, Raymond AA,
• Format: Article
• Language: English
• Published: Penerbit UKM 2009
• Online Access: http://journalarticle.ukm.my/1938/1/04-4%282%29_~_MS_085_%2864-75%29.pdf; http://journalarticle.ukm.my/1938/; http://www.ppukm.ukm.my/ukmmcjournal/index.php

Over-expression of P-glycoprotein (P-gp), the encoded product of the ATP-binding cassette (ABC), sub-family B, member 1 (ABCB1/MDR1) gene, plays an important role in mediating multidrug resistance to antiepileptic drugs (AEDs) in about 30% of patients with epilepsy. Genetic variation may in part exp...