Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients
Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30 of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy p...
Saved in:
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Published: |
2011
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/5071/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.5071 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.50712013-04-18T00:30:34Z http://eprints.um.edu.my/5071/ Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients Haerian, B.S. Lim, K.S. Tan, H.J. Mohamed, E.H.M. Tan, C.T. Raymond, A.A. Wong, C.P. Wong, S.W. Omar, H. Roslan, H. Mohamed, Z. R Medicine Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30 of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy patients. Genotypeswere assessed in 249 drug-resistant and 256 drug-responsive Malaysian patients for C1236T, G2677T/A, and C 5T polymorphisms in the ABCB1 gene. No genotypes, alleles, or haplotypes were associated with the response to VPA in either the overall group or Chinese, Indian, and Malay subgroups. Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy. 2011 Article PeerReviewed Haerian, B.S. and Lim, K.S. and Tan, H.J. and Mohamed, E.H.M. and Tan, C.T. and Raymond, A.A. and Wong, C.P. and Wong, S.W. and Omar, H. and Roslan, H. and Mohamed, Z. (2011) Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients. Epileptic Disorders, 13 (1). pp. 65-75. ISSN 1294-9361 10.1684/epd.2011.0419 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
R Medicine |
spellingShingle |
R Medicine Haerian, B.S. Lim, K.S. Tan, H.J. Mohamed, E.H.M. Tan, C.T. Raymond, A.A. Wong, C.P. Wong, S.W. Omar, H. Roslan, H. Mohamed, Z. Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients |
description |
Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30 of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy patients. Genotypeswere assessed in 249 drug-resistant and 256 drug-responsive Malaysian patients for C1236T, G2677T/A, and C 5T polymorphisms in the ABCB1 gene. No genotypes, alleles, or haplotypes were associated with the response to VPA in either the overall group or Chinese, Indian, and Malay subgroups. Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy. |
format |
Article |
author |
Haerian, B.S. Lim, K.S. Tan, H.J. Mohamed, E.H.M. Tan, C.T. Raymond, A.A. Wong, C.P. Wong, S.W. Omar, H. Roslan, H. Mohamed, Z. |
author_facet |
Haerian, B.S. Lim, K.S. Tan, H.J. Mohamed, E.H.M. Tan, C.T. Raymond, A.A. Wong, C.P. Wong, S.W. Omar, H. Roslan, H. Mohamed, Z. |
author_sort |
Haerian, B.S. |
title |
Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients |
title_short |
Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients |
title_full |
Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients |
title_fullStr |
Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients |
title_full_unstemmed |
Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients |
title_sort |
association between abcb1 polymorphism and response to sodium valproate treatment in malaysian epilepsy patients |
publishDate |
2011 |
url |
http://eprints.um.edu.my/5071/ |
_version_ |
1643687479359832064 |
score |
13.160551 |