GWAS signals revisited using human knockouts

• Main Authors: Maddirevula, Sateesh, AlZahrani, Fatema, Anazi, Shams, Almureikhi, Mariam, Ben-Omran, Tawfeg, Abdel-Salam, Ghada M.H., Hashem, Mais, Ibrahim, Niema, Abdulwahab, Firdous M., Meriki, Neama, Bashiri, Fahad A., Thong, Meow Keong, Muthukumarasamy, Premala, Mazlan, Rifhan Azwani, Shaheen, Ranad, Alkuraya, Fowzan S.
• Format: Article
• Published: Springer Nature 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/21375/; https://doi.org/10.1038/gim.2017.78

Purpose: Genome-wide association studies (GWAS) have been instrumental to our understanding of the genetic risk determinants of complex traits. A common challenge in GWAS is the interpretation of signals, which are usually attributed to the genes closest to the polymorphic markers that display the s...