Identifying gene knockout strategies using a hybrid of bees algorithm and flux balance analysis for in silico optimization of microbial strains

• Main Authors: Yee, Wen Choon, Mohammad, Mohd. Saberi, Deris, Safaai, Chuii, Khim Chong, Lian, En Chai, Ibrahim, Zuwairie, Omatu, Sigeru
• Format: Book Section
• Published: Springer-Verlag. 2012
• Subjects: QA75 Electronic computers. Computer science
• Online Access: http://eprints.utm.my/id/eprint/35806/; http://dx.doi.org/10.1007/978-3-642-28765-7_44

Genome-scale metabolic networks reconstructions from different organisms have become popular in recent years. Genetic engineering is proven to be able to obtain the desirable phenotypes. Optimization algorithms are implemented in previous works to identify the effects of gene knockout on the results...