CRISPR-Cas knockout of miR21 reduces glioma growth

• Main Authors: Nieland, Lisa, Solinge, Thomas S. van, Cheah, Pike See, Morsett, Liza M., Khoury, Joseph El, Rissman, Joseph I., Kleinstiver, Benjamin P., Broekman, Marike L. D., Breakefield, Xandra O., Abels, Erik R.
• Format: Article
• Published: Cell Press 2022
• Online Access: http://psasir.upm.edu.my/id/eprint/100836/; https://www.cell.com/molecular-therapy-family/oncolytics/fulltext/S2372-7705(22)00053-5#

Non-coding RNAs, including microRNAs (miRNAs), support the progression of glioma. miR-21 is a small, non-coding transcript involved in regulating gene expression in multiple cellular pathways, including the regulation of proliferation. High expression of miR-21 has been shown to be a major driver of...