Identifying a gene knockout strategy using a hybrid of the bat algorithm and flux balance analysis to enhance the production of succinate and lactate in Escherichia coli
The current problem for metabolic engineering is how to identify a suitable set of genes for knockout that can improve the production of certain metabolites and sustain the growth rate from the thousands of metabolic networks which are complex and combinatorial. Some approaches, such as OptKnock and...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Korean Society of Industrial Engineering Chemistry
2015
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/55652/ http://dx.doi.org/10.1007/s12257-014-0466-x |
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