2-Aryl-3-(arylideneamino)-1,2-dihydroquinazoline-4(3H)-ones as inhibitors of cholinesterases and self-induced β-amyloid (Aβ) aggregation: biological evaluations and mechanistic insights from molecular dynamics simulations
A series of 2-aryl-3-(arylideneamino)-1,2-dihydroquinazoline-4(3H)-ones were evaluated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and self-induced β-amyloid (Aβ) aggregation. All the compounds were found to inhibit both forms of cholinesterase (IC50 in the range 4-32...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Royal Society of Chemistry
2018
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/20600/ https://doi.org/10.1039/c7ra11872d |
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