PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation
Crosstalk between the phosphatidylinositol 3-kinase (PI3K) and the transforming growth factor-β signalling pathways play an important role in regulating many cellular functions. However, the molecular mechanisms underpinning this crosstalk remain unclear. Here, we report that PI3K signalling antagon...
Saved in:
Main Authors: | Yu, J.S.L., Ramasamy, T.S., Murphy, N., Holt, M.K., Czapiewski, R., Wei, S.K., Cui, W. |
---|---|
Format: | Article |
Published: |
Nature Publishing Group
2015
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/19339/ http://dx.doi.org/10.1038/ncomms8212 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model
by: Salama, Mohamed, et al.
Published: (2018) -
Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2
by: Rostam, Muhamad Ashraf, et al.
Published: (2018) -
The role of specific Smad linker region phosphorylation in TGF-β
mediated expression of glycosaminoglycan synthesizing
enzymes in vascular smooth muscle
by: Rostam, Muhamad Ashraf, et al.
Published: (2016) -
Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation
by: Kamato, Danielle, et al.
Published: (2013) -
Transforming growth factor β-mediated site-specific Smad
linker region phosphorylation in vascular endothelial cells
by: Kamato, Danielle, et al.
Published: (2014)