Phosphorylated and Nonphosphorylated PfMAP2 Are Localized in the Nucleus, Dependent on the Stage ofPlasmodium falciparumAsexual Maturation

• Main Authors: Dahalan, F.A., Sidek, H.M., Murtey, M.D., Embi, M.N., Ibrahim, J., Fei Tieng, L., Zakaria, N.A., Abdul-Aziz, N.M.
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2016
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/17480/1/ZakariaNA_%282016%29.pdf; http://eprints.um.edu.my/17480/; http://dx.doi.org/10.1155/2016/1645097

Plasmodium falciparum mitogen-activated protein (MAP) kinases, a family of enzymes central to signal transduction processes including inflammatory responses, are a promising target for antimalarial drug development. Our study shows for the first time that the P. falciparum specific MAP kinase 2 (PfM...