Novel 2-benzoyl-6-(2,3- dimethoxybenzylidene)-cyclohexenol confers selectivity toward human MLH1 defective cancer cells through synthetic lethality

• Main Authors: Song, Dedrick Soon Seng, Leong, Sze Wei, Ng, Kwok Wen, Abas, Faridah, Shaari, Khozirah, Leong, Chee Onn, Chung, Felicia Fei-Lei, Mai, Chun Wai, Hii, Ling Wei, Tan, Pei Jean, Patel, Vyomesh
• Format: Article
• Language: English
• Published: Sage Publications 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/81492/1/Novel%202-benzoyl-6-%282%2C3-%20dimethoxybenzylidene%29-cyclohexenol%20confers%20selectivity%20toward%20human%20MLH1%20defective%20cancer%20cells%20through%20synthetic%20lethality.pdf; http://psasir.upm.edu.my/id/eprint/81492/; https://pubmed.ncbi.nlm.nih.gov/30897027/

DNA mismatch repair (MMR) deficiency has been associated with a higher risk of developing colorectal, endometrial, and ovarian cancer, and confers resistance in conventional chemotherapy. In addition to the lack of treatment options that work efficaciously on these MMR-deficient cancer patients, the...