Development of live attenuated Enterovirus 71 vaccine strains that confer protection against lethal challenge in mice

• Main Authors: Yee, Pinn Tsin Isabel, Tan, Soon Hao, Ong, Kien Chai, Tan, Kuan Onn, Wong, Kum Thong, Hassan, Sharifah Syed, Poh, Chit Laa
• Format: Article
• Published: Nature Research 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23102/; https://doi.org/10.1038/s41598-019-41285-z

Besides causing mild hand, foot and mouth infections, Enterovirus A71 (EV-A71) is associated with neurological complications and fatality. With concerns about rising EV-A71 virulence, there is an urgency for more effective vaccines. The live attenuated vaccine (LAV) is a more valuable vaccine as it...