Chemopreventive effects of a curcumin‐like diarylpentanoid [2,6‐bis(2,5‐dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro

• Main Authors: Lee, Ka Heng, Abas, Faridah, Mohammed Alitheen, Noorjahan Banu, Shaari, Khozirah, Lajis, Nordin, Israf Ali, Daud Ahmad, Ahmad, Syahida
• Format: Article
• Language: English
• Published: Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/36780/1/36780.pdf; http://psasir.upm.edu.my/id/eprint/36780/; https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.12341

Aim: Synovial fibroblast has emerged as a potential cellular target in progressive joint destruction in rheumatoid arthritis development. In this study, BDMC 33 (2,6‐bis[2,5‐dimethoxybenzylidene]cyclohexanone), a curcumin analogue with enhanced anti‐inflammatory activity has been synthesized and the...